Expression of autocrine motility factor receptor in cutaneous malignant melanoma.

Abstract

BACKGROUND:

The autocrine motility factor receptor (AMFR), a specific receptor for AME, is considered to be related to the metastatic potential of tumor cells.

OBJECTIVE:

We investigated whether AMFR is expressed on cutaneous malignant melanoma cells and has any relationship to clinical stage and metastatic ability.

METHODS:

We performed an immunohistochemical study on 20 cases of cutaneous malignant melanoma using anti-AMFR antibody. AMFR was expressed in 9 cases (45%), and its expression had a tendency to correlate with the clinical stage and the presence of lymph node metastasis.

CONCLUSIONS:

The expression of AMFR may have a possible association with the metastatic potential of malignant melanoma.

• Authors: Y Nagai, O Ishikawa, Y Miyachi, H Watanabe
• Journal: Dermatology (Basel, Switzerland) (Dermatology) Vol. 192 Issue 1 Pg. 8-11 ( 1996) ISSN: 1018-8665 [Print] Switzerland
• PMID: 8832943 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Receptors, Cytokine
• AMFR protein, human
• Receptors, Autocrine Motility Factor
• Ubiquitin-Protein Ligases

Topics

• Biopsy, Needle
• Diagnosis, Differential
• Dysplastic Nevus Syndrome (pathology)
• Humans
• Immunohistochemistry
• Lymphatic Metastasis
• Melanoma (pathology, secondary)
• Neoplasm Metastasis
• Neoplasm Staging
• Receptors, Autocrine Motility Factor
• Receptors, Cytokine (analysis)
• Reference Values
• Retrospective Studies
• Sensitivity and Specificity
• Skin Neoplasms (pathology)
• Ubiquitin-Protein Ligases