Topical lomefloxacin twice daily compared with fucidic acid in acute bacterial conjunctivitis.

Abstract

Forty-five patients with presumed acute bacterial conjunctivitis were treated in an investigator-masked randomized multicenter study with either lomefloxacin 0.3% or fucidic acid 1% eye drops twice daily. Clinical signs and symptoms were rated by slit-lamp examination and conjunctival swab cultures were performed to evaluate clinical and microbiological efficacy. A total of 57 ocular isolates were tested for susceptibility to nine antibiotics. A significant decrease in clinical symptomatology was achieved by both treatments with a gradual improvement over the treatment period of 7-9 days. Bacteriological recovery was frequently achieved already at the first control visit (day 3-5), but the recovery rate was statistically significant (p = 0.014) only in the lomefloxacin group. The relatively high in vitro resistance rate (46%) to fucidic acid was not reflected by lower clinical efficacy. Two unrelated adverse events (one in each treatment group) and minimal local intolerance problems were observed in both treatment groups. A significantly higher incidence of burning sensation was observed with fucidic acid than with lomefloxacin (p < 0.01). All four treatment failures in the study occurred in the fucidic acid group. Lomefloxacin 0.3% ophthalmic solution demonstrated a high efficacy and good tolerance in the management of acute bacterial conjunctivitis.

• Authors: K Malminiemi, O Kari, M L Latvala, R Voutilainen, A Miettinen, A Jauch
• Journal: Acta ophthalmologica Scandinavica (Acta Ophthalmol Scand) Vol. 74 Issue 3 Pg. 280-4 (Jun 1996) ISSN: 1395-3907 [Print] Denmark
• PMID: 8828727 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Multicenter Study, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)

Chemical References

• Anti-Bacterial Agents
• Anti-Infective Agents
• Fluoroquinolones
• Ophthalmic Solutions
• Quinolones
• Fusidic Acid
• lomefloxacin

Topics

• Acute Disease
• Administration, Topical
• Anti-Bacterial Agents (administration & dosage, adverse effects, therapeutic use)
• Anti-Infective Agents (administration & dosage, therapeutic use)
• Bacteria (isolation & purification)
• Colony Count, Microbial
• Conjunctiva (microbiology)
• Conjunctivitis, Bacterial (drug therapy, pathology)
• Double-Blind Method
• Drug Resistance
• Fluoroquinolones
• Fusidic Acid (administration & dosage, adverse effects, therapeutic use)
• Humans
• Microbial Sensitivity Tests
• Ophthalmic Solutions
• Quinolones (administration & dosage, therapeutic use)