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Prevention of catheter-related infections by silver coated central venous catheters in oncological patients.

Abstract
Catheter-related infection (CRI) is a serious complication of central venous catheterization. We have investigated the efficacy of a silver-coated polyurethane catheter (Pellethane, Fresenius AG, Germany) in preventing CRI in oncological patients receiving chemotherapy in a phase II study. From November 1992 through April 1994, 266 patients were assigned to receive single lumen catheters, either standard uncoated catheters (UC, n = 113) or silver-coated ones (SC, n = 120). Catheters were inserted into the internal jugular vein after institutional approval and informed consent. Duration of catheterization (UC vs. SC = 13.3 vs. 12.7 days) and leukopenia (< 1.0 x 10(9) WBC/l; 4.3 vs. 3.6 days) were similar in both groups demonstrating a comparable risk for infections. Skin reactions at the catheter entry site were recorded daily. CRI and colonization rates were studied by semiquantitatively culturing intradermal and intravascular segments. CRI were confirmed by blood cultures obtained via catheter and from peripheral veins in cases of suspected sepsis or at the end of catheterization. No adverse effects from the silver-coated catheter could be observed. The bacteriological results showed that SC were colonized (> 15 CFU) in 45.1% and UC in 44.2%. CRI developed in 21.2% of the UC patients but only in 10.2% of the SC patients (p = 0.011). We conclude that this new silver-coated central venous catheter is biocompatible and effective in reducing the incidence of catheter-related infections in oncological patients.
AuthorsH Goldschmidt, U Hahn, H J Salwender, R Haas, B Jansen, P Wolbring, M Rinck, W Hunstein
JournalZentralblatt fur Bakteriologie : international journal of medical microbiology (Zentralbl Bakteriol) Vol. 283 Issue 2 Pg. 215-23 (Dec 1995) ISSN: 0934-8840 [Print] Germany
PMID8825113 (Publication Type: Clinical Trial, Controlled Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Polyurethanes
  • Silver
Topics
  • Adolescent
  • Adult
  • Aged
  • Bacterial Infections (complications, prevention & control)
  • Catheterization, Central Venous (adverse effects, instrumentation)
  • Female
  • Gram-Positive Bacteria (growth & development)
  • Humans
  • Male
  • Middle Aged
  • Neoplasms (complications)
  • Polyurethanes (chemistry)
  • Prospective Studies
  • Pseudomonas aeruginosa (growth & development)
  • Sepsis (prevention & control)
  • Silver (chemistry)

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