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Analgesic, anti-inflammatory, antipyretic and haematological effects of aethiopinone, an o-naphthoquinone diterpenoid from Salvia aethiopis roots and two hemisynthetic derivatives.

Abstract
Aethiopinone (1), an o-naphthoquinone diterpene from Salvia aethiopis L. roots and two hemisynthetic derivatives 2 and 3 have been evaluated for toxicity, anti-inflammatory, analgesic, antipyretic, and haemostatic activities. The compounds tested showed low toxicity and a pharmacological profile similar to other NSAI substances on reducing the edema induced by carrageenan and contractions induced by phenyl-p-quinone; the most active compounds were 1 and 2. In the same way and as expected with these types of substances, the bleeding time increased. In the TPA-induced ear inflammation model, the three compounds showed a moderate reduction of edema, and 1 produced a significant increase in the reaction time against thermal painful stimuli in the tail immersion test. The results demonstrated strong anti-inflammatory, peripheral and central analgesic properties for 1, as well as antiedematose topical action and peripheral analgesic properties for 2 and 3.
AuthorsM Hernández-Pérez, R M Rabanal, M C de la Torre, B Rodríguez
JournalPlanta medica (Planta Med) Vol. 61 Issue 6 Pg. 505-9 (Dec 1995) ISSN: 0032-0943 [Print] Germany
PMID8824942 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Analgesics
  • Analgesics, Non-Narcotic
  • Anti-Inflammatory Agents, Non-Steroidal
  • Coagulants
  • Naphthoquinones
  • aethiopinone
Topics
  • Analgesics (pharmacology)
  • Analgesics, Non-Narcotic (pharmacology)
  • Animals
  • Anti-Inflammatory Agents, Non-Steroidal (pharmacology)
  • Coagulants (pharmacology)
  • Female
  • Male
  • Mice
  • Naphthoquinones (pharmacology)
  • Plant Roots (chemistry)
  • Rats
  • Rats, Wistar

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