Abstract |
Aethiopinone (1), an o-naphthoquinone diterpene from Salvia aethiopis L. roots and two hemisynthetic derivatives 2 and 3 have been evaluated for toxicity, anti-inflammatory, analgesic, antipyretic, and haemostatic activities. The compounds tested showed low toxicity and a pharmacological profile similar to other NSAI substances on reducing the edema induced by carrageenan and contractions induced by phenyl-p- quinone; the most active compounds were 1 and 2. In the same way and as expected with these types of substances, the bleeding time increased. In the TPA-induced ear inflammation model, the three compounds showed a moderate reduction of edema, and 1 produced a significant increase in the reaction time against thermal painful stimuli in the tail immersion test. The results demonstrated strong anti-inflammatory, peripheral and central analgesic properties for 1, as well as antiedematose topical action and peripheral analgesic properties for 2 and 3.
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Authors | M Hernández-Pérez, R M Rabanal, M C de la Torre, B Rodríguez |
Journal | Planta medica
(Planta Med)
Vol. 61
Issue 6
Pg. 505-9
(Dec 1995)
ISSN: 0032-0943 [Print] Germany |
PMID | 8824942
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Analgesics
- Analgesics, Non-Narcotic
- Anti-Inflammatory Agents, Non-Steroidal
- Coagulants
- Naphthoquinones
- aethiopinone
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Topics |
- Analgesics
(pharmacology)
- Analgesics, Non-Narcotic
(pharmacology)
- Animals
- Anti-Inflammatory Agents, Non-Steroidal
(pharmacology)
- Coagulants
(pharmacology)
- Female
- Male
- Mice
- Naphthoquinones
(pharmacology)
- Plant Roots
(chemistry)
- Rats
- Rats, Wistar
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