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Lymphoid involvement in a patient with acute myeloid leukemia: a direct phenotypic and genotypic study of single cells.

Abstract
Lymphoid involvement in acute myeloid leukemia (AML) was studied using the morphology-antibody-chromosome (MAC) combination technique in one patient. The chromosomal aberration, trisomy 8, was demonstrated in AML blasts, glycophorin A-positive erythroblasts, and CD3- and CD20/22-positive small lymphocytes. This suggests that in this patient even lymphocytes belonged to the leukemic clone.
AuthorsW El-Rifai, M L Larramendy, T Ruutu, S Knuutila
JournalGenes, chromosomes & cancer (Genes Chromosomes Cancer) Vol. 15 Issue 1 Pg. 34-7 (Jan 1996) ISSN: 1045-2257 [Print] United States
PMID8824723 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Topics
  • Acute Disease
  • Aged
  • Cell Differentiation
  • Chromosomes, Human, Pair 8
  • Female
  • Genotype
  • Humans
  • Immunophenotyping
  • Leukemia, Myeloid (genetics, immunology, pathology)
  • Phenotype
  • Trisomy
  • Tumor Cells, Cultured

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