Abstract | OBJECTIVE: DESIGN: An animal intervention study. METHODS: RESULTS: There was a dose-dependent improvement in macroscopic scores (2.4 and 3.2 mg/kg: P < 0.02, P < 0.001) and myeloperoxidase levels (3.2 mg/kg: P < 0.04). Dialysate LTB4 levels fell (2.4 and 3.2 mg/kg: P < 0.03, P < 0.02) as did PGE2 levels. TXB2 concentrations remained unaffected. CONCLUSION: The PAF receptor antagonist BB-882 shows efficacy in treating inflammation in an animal model of acute colitis as evidenced by a dose-dependent fall in macroscopic mucosal damage, neutrophil infiltration and reduced generation of inflammatory mediators.
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Authors | J Meenan, T A Grool, D W Hommes, S Dijkhuizen, F J ten Kate, M Wood, M Whittaker, G N Tytgat, S J van Deventer |
Journal | European journal of gastroenterology & hepatology
(Eur J Gastroenterol Hepatol)
Vol. 8
Issue 6
Pg. 569-73
(Jun 1996)
ISSN: 0954-691X [Print] England |
PMID | 8823572
(Publication Type: Journal Article)
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Chemical References |
- BB 882
- Platelet Membrane Glycoproteins
- Receptors, Cell Surface
- Receptors, G-Protein-Coupled
- platelet activating factor receptor
- Formaldehyde
- Leukotriene B4
- Thromboxane B2
- Leucine
- Dinoprostone
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Topics |
- Animals
- Colitis
(chemically induced, drug therapy)
- Dinoprostone
(analysis)
- Disease Models, Animal
- Dose-Response Relationship, Drug
- Enzyme-Linked Immunosorbent Assay
- Formaldehyde
- Injections, Intravenous
- Intestinal Mucosa
(drug effects, pathology)
- Leucine
(administration & dosage, analogs & derivatives, therapeutic use)
- Leukotriene B4
(analysis)
- Male
- Platelet Membrane Glycoproteins
(antagonists & inhibitors, therapeutic use)
- Rabbits
- Receptors, Cell Surface
- Receptors, G-Protein-Coupled
- Thromboxane B2
(analysis)
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