Abstract |
We report a patient who presented with transient diabetes insipidus in pregnancy on a background of previous postoperative diabetes insipidus following surgical excision of a prolactinoma. The patient illustrates how the complex changes in water homeostasis occurring during normal pregnancy may unmask latent diabetes insipidus. The major factors operating appear to be a physiological reduction in the thresholds for thirst and arginine vasopressin secretion coupled with a substantial increase in placental clearance of arginine vasopressin. Reversal of these changes after delivery results in normalization of the disordered water homeostasis, with consequent resolution of the diabetes insipidus.
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Authors | S G Soule, J P Monson, H S Jacobs |
Journal | Human reproduction (Oxford, England)
(Hum Reprod)
Vol. 10
Issue 12
Pg. 3322-4
(Dec 1995)
ISSN: 0268-1161 [Print] England |
PMID | 8822468
(Publication Type: Case Reports, Journal Article)
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Chemical References |
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Topics |
- Adult
- Arginine Vasopressin
(metabolism)
- Body Water
(metabolism)
- Diabetes Insipidus
(complications, metabolism)
- Female
- Homeostasis
- Humans
- Pituitary Neoplasms
(complications, surgery)
- Placenta
(metabolism)
- Pregnancy
- Pregnancy in Diabetics
(etiology, metabolism)
- Prolactinoma
(complications, surgery)
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