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Insulin-degrading activity in experimental liver cirrhosis of the rat.

Abstract
Liver cirrhosis in man is often associated with hyperinsulinemia but its pathogenesis is still unexplained. To investigate whether insulin degradation is impaired in cirrhotic liver, the specific insulin-degrading enzyme activity (EC 3.4.22.11) was assayed in liver cytosol of rats with CCl4-induced liver cirrhosis. No difference was found between liver cytosol of cirrhotic and control rats. The results show that experimental CCl4-induced liver cirrhosis does not damage the specific insulin-degrading activity and support the hypothesis that impaired hepatic insulin handling is not an important cause of hyperinsulinemia in liver cirrhosis.
AuthorsM Auletta, S Antoniello, N Abrescia
JournalEnzyme & protein (Enzyme Protein) 1994-1995 Vol. 48 Issue 4 Pg. 197-201 ISSN: 1019-6773 [Print] Switzerland
PMID8821707 (Publication Type: Journal Article)
Chemical References
  • Insulin
  • Carbon Tetrachloride
  • Insulysin
Topics
  • Animals
  • Carbon Tetrachloride (pharmacology)
  • Cytoplasm (enzymology, metabolism)
  • Insulin (blood, metabolism)
  • Insulysin (metabolism)
  • Liver Cirrhosis, Experimental (enzymology, metabolism)
  • Male
  • Rats
  • Rats, Wistar

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