Evaluation of atovaquone in the treatment of patients with uncomplicated Plasmodium falciparum malaria.

Abstract

The activity of atovaquone in patients with oligosymptomatic Plasmodium falciparum malaria was assessed in an open, non-comparative clinical study. The patients showed a good clinical response, but there was a high rate of recrudescence. The activity of atovaquone in combination with another antimalarial agent should be investigated.

• Authors: P L Chiodini, C P Conlon, D B Hutchinson, J A Farquhar, A P Hall, T E Peto, H Birley, D A Warrell
• Journal: The Journal of antimicrobial chemotherapy (J Antimicrob Chemother) Vol. 36 Issue 6 Pg. 1073-8 (Dec 1995) ISSN: 0305-7453 [Print] England
• PMID: 8821609 (Publication Type: Clinical Trial, Journal Article)

Chemical References

• Antimalarials
• Naphthoquinones
• Atovaquone

Topics

• Adult
• Antimalarials (adverse effects, blood, therapeutic use)
• Atovaquone
• Dose-Response Relationship, Drug
• Drug Administration Schedule
• Evaluation Studies as Topic
• Humans
• Malaria, Falciparum (blood, drug therapy)
• Male
• Middle Aged
• Naphthoquinones (adverse effects, blood, therapeutic use)
• Treatment Outcome