Abstract |
Orally administered barbaloin (100 mg/kg) did not induce any diarrhea in male Wistar rats, in spite of severe diarrhea with sennoside B (40 mg/kg). Also, in gnotobiote rats mono-associated with Peptostreptococcus intermedius, a human intestinal anaerobe capable of reducing sennidins to rhein anthrone, barbaloin did not induce diarrhea; the faecal water content (71.9%) 8 h after the administration of barbaloin was not increased, compared with that (73.9%) just before the treatment. However, severe diarrhea was induced with barbaloin in gnotobiote rats mono-associated with Eubacterium sp. strain BAR, another human intestinal anaerobe capable of transforming barbaloin to aloe-emodin anthrone; the faecal water content was significantly increased to 85.5% 8 h after the administration, from 73.2% before the treatment. At this time, barbaloin was transformed to aloe-emodin anthrone in the feces from the gnotobiote rats mono-associated with the strain BAR, but not in feces from the conventional rats or the gnotobiote rats mono-associated with P. intermedius. These facts indicate that barbaloin is inactive as a laxative itself but is activated to aloe-emodin anthrone, a genuine purgative component, by Eubacterium sp. strain BAR.
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Authors | T Akao, Q M Che, K Kobashi, M Hattori, T Namba |
Journal | Biological & pharmaceutical bulletin
(Biol Pharm Bull)
Vol. 19
Issue 1
Pg. 136-8
(Jan 1996)
ISSN: 0918-6158 [Print] Japan |
PMID | 8820926
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Anthracenes
- Anthraquinones
- Cathartics
- Culture Media
- barbaloin
- aloe emodin
- Emodin
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Topics |
- Animals
- Anthracenes
(metabolism, pharmacology)
- Anthraquinones
- Cathartics
(metabolism, pharmacology)
- Culture Media
- Diarrhea
(chemically induced)
- Emodin
(pharmacology)
- Eubacterium
(metabolism)
- Feces
(microbiology)
- Intestines
(microbiology, physiology)
- Male
- Rats
- Rats, Wistar
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