[The effect of the blood corrective agent Lactosorbal on liver functional activity in dogs with a model of severe hemorrhagic shock].

Abstract

A new complex action hemocorrective <<Lactosorbal>> was studied for its effect on functional activity of the liver, for which purpose a total of 5 dogs subjected to severe hemorrhagic shock were used. Apart from marked hemodynamic effects the <<Lactosorbal>> intravenous transfusions (10 ml/kg) promote restoration of hepatic functions and survival of animals. Possible modes of action responsible for therapeutic effect of <<Lactosorbal>> are considered. The results of the present study serve to experimentally substentiate the use of <<Lactosorbal>> in combined therapy of grave forms of shock of different genesis during all stages of medical evacuation as well as of acute renal insufficiency in clinical settings.

• Authors: A N Oborin, M V Mindiuk
• Journal: Likars'ka sprava (Lik Sprava) 1995 Mar-Apr Issue 3-4 Pg. 152-4 ISSN: 1019-5297 [Print] Ukraine
• Vernacular Title: Vliianie gemokorrektora "Laktosorbal" na funktsional'nuiu aktivnost' pecheni u sobak s modelirovannym tiazhelym gemorragicheskim shokom.
• PMID: 8819952 (Publication Type: English Abstract, Journal Article)

Chemical References

• Blood Substitutes
• Serum Albumin
• lactosorbal
• Sorbic Acid

Topics

• Acute Disease
• Animals
• Blood Substitutes (therapeutic use)
• Disease Models, Animal
• Dogs
• Drug Evaluation, Preclinical
• Female
• Liver (drug effects, physiopathology)
• Male
• Serum Albumin (therapeutic use)
• Shock, Hemorrhagic (physiopathology, therapy)
• Sorbic Acid (therapeutic use)
• Time Factors