Effect of sub-lethal doses of albendazole on the fecundity of Dictyocaulus viviparus.

Abstract

During an evaluation of the efficacy of prolonged low-dose albendazole therapy on nematode infections in calves, it was observed that a dose-rate of 2 mg kg-1 given daily for 10 days was highly effective at expelling Dictyocaulus viviparus, but smaller doses suppressed the faecal output of larvae without killing the lungworms. A more detailed study with four experimentally infected calves given 1 mg kg-1 day-1 for 10 days showed that faecal output of larvae ceased after six to eight days but resumed four to six days after the withdrawal of the drug. The albendazole-induced sterility was therefore reversible. A subsidiary study showed that the strain of parasite used was fully susceptible to albendazole.

• Authors: A M Osman, D E Jacobs, M A Fisher, J G Pilkington, P A Jones
• Journal: Research in veterinary science (Res Vet Sci) Vol. 61 Issue 1 Pg. 92-3 (Jul 1996) ISSN: 0034-5288 [Print] England
• PMID: 8819203 (Publication Type: Journal Article)

Chemical References

• Anthelmintics
• Albendazole

Topics

• Albendazole (pharmacology, therapeutic use)
• Animals
• Anthelmintics (pharmacology, therapeutic use)
• Cattle
• Dictyocaulus (physiology)
• Dictyocaulus Infections (drug therapy)
• Feces (parasitology)
• Fertility (drug effects)
• Larva
• Male