Abstract | OBJECTIVE: To determine whether a diuretic can also reverse the clinical, systemic, renal and glomerular haemodynamic and pathological changes caused by nephrosclerosis. METHODS: RESULTS: The mean arterial pressure, cardiac output, effective renal plasma flow and glomerular filtration rate decreased as urinary volume increased in the SHR treated with HCTZ and L-NAME. A micropuncture study demonstrated increased glomerular capillary pressure (PG, 56 +/- 1 versus 68 +/- 3 mmHg) associated with increased efferent (2.1 +/- 0.2 versus 2.9 +/- 0.3 u) but no change in afferent arteriolar resistances compared with the SHR group treated with L-NAME only. In addition, HCTZ administration increased the juxtamedullary glomerular injury score (47 +/- 13 versus 114 +/- 29) associated with elevated urinary protein excretion (35 +/- 1 versus 53 +/- 13 mg/100 g body weight per 24 h) The afferent arteriolar injury score was not changed. The PG elevation was related not only to severe glomerulosclerosis but also to increased fibronectin and alpha-smooth muscle actin deposition. CONCLUSION:
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Authors | Y Ono, H Ono, E D Frohlich |
Journal | Journal of hypertension
(J Hypertens)
Vol. 14
Issue 7
Pg. 823-8
(Jul 1996)
ISSN: 0263-6352 [Print] England |
PMID | 8818920
(Publication Type: Journal Article)
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Chemical References |
- Antihypertensive Agents
- Diuretics
- Sodium Chloride Symporter Inhibitors
- Hydrochlorothiazide
- Nitric Oxide Synthase
- NG-Nitroarginine Methyl Ester
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Topics |
- Animals
- Antihypertensive Agents
(pharmacology, therapeutic use)
- Diuretics
- Hemodynamics
(drug effects)
- Hydrochlorothiazide
(pharmacology, therapeutic use)
- Hypertension
(chemically induced, drug therapy)
- Kidney
(drug effects, pathology)
- Male
- NG-Nitroarginine Methyl Ester
(pharmacology)
- Nephrosclerosis
(chemically induced, drug therapy, pathology, physiopathology)
- Nitric Oxide Synthase
(antagonists & inhibitors)
- Proteinuria
(drug therapy)
- Rats
- Rats, Inbred SHR
- Renal Circulation
(drug effects)
- Sodium Chloride Symporter Inhibitors
(pharmacology, therapeutic use)
- Vascular Resistance
(drug effects)
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