Abstract | OBJECTIVE: DESIGN: Prospective study. SETTING: Teaching hospital, Sweden. SUBJECTS: INTERVENTIONS: Aspiration of bile from the gallbladder during operation. MAIN OUTCOME MEASURES: RESULTS: There were no differences in total protein content among the groups except for the UDCA treated group, which had significantly less protein 2.1 (0.5) g/l compared with 6.1 (0.5) for untreated gallstones, 5.8 (0.9) for those treated with CDCA, 6.8 (1.2) for those treated with aspirin and 7.3 (0.7) for those with no gallstones). There were no differences between bile with and without crystals. There was a positive correlation between the protein content and biliary cholesterol concentration and saturation. Aspirin did not influence the total protein content in the bile. CONCLUSIONS: The total protein concentration in gallbladder bile was similar in patients with and without cholesterol crystals, which might indicate that the total protein content in bile does not influence formation of cholesterol crystals and consequently not the formation of gallstones. Patients treated with UDCA were the only group that had significantly less protein than the other groups, which indicates that the mode of action of UDCA is different from that of CDCA.
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Authors | S Sahlin |
Journal | The European journal of surgery = Acta chirurgica
(Eur J Surg)
Vol. 162
Issue 6
Pg. 463-9
(Jun 1996)
ISSN: 1102-4151 [Print] England |
PMID | 8817223
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Lipids
- Proteins
- Chenodeoxycholic Acid
- Ursodeoxycholic Acid
- Cholesterol
- Aspirin
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Topics |
- Aspirin
(therapeutic use)
- Bile
(chemistry)
- Chenodeoxycholic Acid
(therapeutic use)
- Cholelithiasis
(chemistry, drug therapy, metabolism)
- Cholesterol
(analysis)
- Female
- Humans
- Lipids
(analysis)
- Male
- Middle Aged
- Prospective Studies
- Proteins
(analysis)
- Ursodeoxycholic Acid
(therapeutic use)
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