Increased plasma concentration of fibrin monomer in acute myocardial infarction with early reperfusion.

Abstract

OBJECTIVE:

To assess whether plasma fibrin monomer (FM) concentration, a marker of thrombin activity, is increased in the first hours after acute coronary occlusion and whether there are differences between patients with and without early reperfusion.

DESIGN:

Thirty-five consecutive patients with acute myocardial infarction (AMI) and early coronary angiography were studied prospectively.

METHODS:

Plasma FM samples taken on admission (< 6 h after onset of chest pain) and 6-14 h after onset of chest pain were analysed using a specific enzyme immunoassay. All of the patients were anticoagulated with heparin intravenously.

RESULTS:

Of the 35 patients, 28 had angiographically documented reperfusion within the first 6 h, whereas seven patients had no early reperfusion. FM concentrations were measured in the reference range (< or = 3.6 mg/l) within the first 6 h in 32 of the 35 patients. At 6-14 h FM concentrations were elevated in the reperfusion group (median 4.56 mg/l), but not in the group without reperfusion (median 1.6 mg/l, P = 0.0063). Using a threshold value of 3.0 mg/l, sensitivity and specificity of FM for the non-invasive recognition of early reperfusion were 78 and 83%, respectively. The specificity was similar to that for troponin T and higher than the creatinine kinase MB specificity.

CONCLUSIONS:

FM plasma concentrations are elevated in patients with AMI and early reperfusion. With a single blood sample 6-14 h after onset of chest pain, FM analysis is useful for the non-invasive detection of early reperfusion after AMI.

• Authors: M Spiecker, G Hafner, U Nixdorff, W Prellwitz, J Meyer
• Journal: Coronary artery disease (Coron Artery Dis) Vol. 7 Issue 2 Pg. 155-60 (Feb 1996) ISSN: 0954-6928 [Print] England
• PMID: 8813448 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Anticoagulants
• Biomarkers
• Fibrin Fibrinogen Degradation Products
• Troponin
• Troponin T
• fibrinmonomer
• Heparin
• Creatine Kinase

Topics

• Anticoagulants (administration & dosage)
• Biomarkers (blood)
• Coronary Angiography
• Creatine Kinase (blood)
• Female
• Fibrin Fibrinogen Degradation Products (drug effects, metabolism)
• Heparin (administration & dosage)
• Humans
• Immunoenzyme Techniques
• Infusions, Intravenous
• Male
• Middle Aged
• Myocardial Infarction (blood, diagnostic imaging, drug therapy)
• Myocardial Reperfusion
• Prospective Studies
• Sensitivity and Specificity
• Troponin (blood)
• Troponin T