HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Is activation of metabotropic glutamate receptors responsible for acute hyposic changes in hippocampal neurons?

Abstract
In whole-cell recordings from CA1 neurons in slices from rats, the mGLUR agonist (+/-)-1-aminocyclopentane-trans-1,3-dicarboxylic acid (ACPD; 10 microM) had a depolarizing action on most cells, associated with an increase in input resistance and suppression of afterhyperpolarizations. Under voltage-clamp, there were corresponding changes in membrane current and conductance; in the presence of ACPD, the slow voltage-dependent outward current recorded at approximately -25 mV was smaller and was more clearly depressed by hypoxia. Neither ACPD nor mGLUR antagonists, L(+)-2-amino-3-phosphonoproprionic acid (L-AP3; 1 mM) and (+)-alpha-methyl-4-carboxyphenyl-glycine (MCPG; 0.5 mM), reduced the hyperpolarization or outward current (or the associated changes in input resistance or conductance) induced by 2 min of hypoxia. Early inward currents, corresponding to the early, transient depolarizing effect of hypoxia, wer also not significantly depressed by either MCPG or L-AP3. The hypoxic responses of CA1 neurons in slices are therefore unlikely to be caused mainly be glutamate release and activation of mGLURs.
AuthorsG Erdemli, Krnjević
JournalBrain research (Brain Res) Vol. 723 Issue 1-2 Pg. 1-7 (Jun 03 1996) ISSN: 0006-8993 [Print] Netherlands
PMID8813376 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Receptors, Metabotropic Glutamate
  • Cycloleucine
  • 1-amino-1,3-dicarboxycyclopentane
Topics
  • Animals
  • Cycloleucine (analogs & derivatives, pharmacology)
  • Hippocampus (drug effects)
  • Hypoxia (physiopathology)
  • Male
  • Membrane Potentials (drug effects)
  • Patch-Clamp Techniques
  • Rats
  • Rats, Sprague-Dawley
  • Receptors, Metabotropic Glutamate (drug effects)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: