A cationic polymer, Eudragit-E, as a new liquid embolic material for arteriovenous malformations.

Abstract

We have developed a new liquid material for embolisation of arteriovenous malformations: a mixture of methyl and butyl methacrylate, plus dimethylaminoethyl methacrylate copolymer (Eudragit-E) in a solvent consisting of ethanol and iopamidol. Upon contact with aqueous substances, Eudragit-E precipitates rapidly and forms a soft elastic sponge within 3 s, as the ethanol diffuses. In blood, the positively charged Eudragit-E aggregates the negatively charged blood elements. Transcatheter embolisation of 4 canine and 52 rat renal arteries was feasible. Histological studies revealed no acute inflammatory reaction within 1 week, but mild to moderate reactions in the subacute and chronic stages. No recanalisation was seen. Because of its unique properties and excellent thrombogenicity the Eudragit-E, mixture seems a promising embolic material.

• Authors: K Yamashita, W Taki, H Iwata, H Kikuchi
• Journal: Neuroradiology (Neuroradiology) Vol. 38 Suppl 1 Pg. S151-6 (May 1996) ISSN: 0028-3940 [Print] Germany
• PMID: 8811703 (Publication Type: Journal Article)

Chemical References

• Biocompatible Materials
• Methacrylates
• Methylmethacrylates
• Eudragit-E

Topics

• Analysis of Variance
• Animals
• Arteriovenous Malformations (therapy)
• Biocompatible Materials
• Catheterization, Peripheral (methods)
• Dogs
• Embolization, Therapeutic (methods)
• Endothelium, Vascular (drug effects)
• Follow-Up Studies
• Inflammation (etiology)
• Infusions, Intra-Arterial
• Materials Testing
• Methacrylates (administration & dosage, adverse effects, chemistry)
• Methylmethacrylates
• Radiography
• Rats
• Rats, Wistar
• Renal Artery (diagnostic imaging)
• Viscosity