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Variation of serum potassium and creatinine phosphokinase levels in suxamethonium-induced muscle relaxation.

Abstract
Popular depolarising muscle relaxant, suxamethonium (succinylcholine chloride), produces fasciculation in group of muscles and 'after pain'. Mode of its action is neuromuscular blockage. It also may be associated with muscle fibre injury and altered membrane permeability. These may cause rise of serum K+ and creatinine phosphokinase (CPK) levels. But use of diazepam either during or as pretreatment may reduce the fasciculation, 'after pain' and rise of K+ and CPK levels. Present study was undertaken to show whether any correlation of the degree of fasciculation and postsuxamethonium myalgia is present or not and whether diazepam has any role in reducing muscle injury and in turn reducing the levels of serum K+ and CPK.
AuthorsA Guha, B N Das, S Sengupta, B K Das
JournalJournal of the Indian Medical Association (J Indian Med Assoc) Vol. 94 Issue 2 Pg. 45-6 (Feb 1996) ISSN: 0019-5847 [Print] India
PMID8810174 (Publication Type: Clinical Trial, Comparative Study, Controlled Clinical Trial, Journal Article)
Chemical References
  • Anesthetics, Intravenous
  • Neuromuscular Depolarizing Agents
  • Creatine Kinase
  • Succinylcholine
  • Thiopental
  • Diazepam
Topics
  • Adult
  • Anesthetics, Intravenous (therapeutic use)
  • Creatine Kinase (blood)
  • Diazepam (therapeutic use)
  • Drug Therapy, Combination
  • Female
  • Humans
  • Hyperkalemia (chemically induced)
  • Male
  • Neuromuscular Depolarizing Agents (adverse effects)
  • Pain (chemically induced)
  • Postoperative Complications (chemically induced)
  • Succinylcholine (adverse effects)
  • Thiopental (therapeutic use)

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