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Anthracycline dose intensity: clinical pharmacology and pharmacokinetics of high-dose doxorubicin administered as a 96-hour continuous intravenous infusion.

Abstract
In this review, the clinical pharmacology of high-dose doxorubicin is examined, and the pharmacokinetics of infusional doxorubicin at standard and high dose are compared. The data developed here, including recent clinical trials of high-dose infusional doxorubicin, demonstrate the safety and efficacy of doxorubicin administration at doses > or = 150 mg/m2 for patients with breast cancer and strongly suggest that the utility of this drug can be substantially increased with appropriate hematopoietic support.
AuthorsT W Synold, J H Doroshow
JournalThe Journal of infusional chemotherapy (J Infus Chemother) Vol. 6 Issue 2 Pg. 69-73 ( 1996) ISSN: 1060-0051 [Print] UNITED STATES
PMID8809652 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S., Review)
Chemical References
  • Antibiotics, Antineoplastic
  • Doxorubicin
Topics
  • Antibiotics, Antineoplastic (administration & dosage, pharmacokinetics)
  • Clinical Trials as Topic
  • Dose-Response Relationship, Drug
  • Doxorubicin (administration & dosage, pharmacokinetics)
  • Drug Administration Schedule
  • Humans
  • Infusions, Intravenous
  • Neoplasms (drug therapy)

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