Abstract | CONCLUSION: BACKGROUND: PATIENTS AND METHODS: The study included 40 patients (22 female, 18 male; mean age 51 yr, range 22-88 yr) with AP and 7 patients (2 female, 5 male; mean age 37 yr, range 25-49 yr) with type I diabetes and renal insufficiency who underwent simultaneous kidney and pancreas transplantation. By means of contrast-enhanced computed tomography (CT) and/or intraoperative findings, patients were judged to have edematous-interstitial (AIP, n = 20, mean age 55.2 yr, range 24-88 yr) or necrotizing pancreatitis (NP, n = 20, mean age 46.3 yr, range 22-81 yr). Serum hPASP concentration was measured daily by a commercial radioimmunoassay technique. In 25 healthy subjects and in several control groups (35 patients with chronic pancreatitis, 20 patients with pancreatic carcinoma and 80 patients with different gastrointestinal diseases) a single blood specimen was taken at hospital admission for the determination of the normal range of hPASP and for specificity analysis. RESULTS: The upper normal value for hPASP in healthy subjects was found to be 52 ng/mL. Serum hPASP was elevated in all patients suffering from AP, with a median of 343 ng/mL (lower-upper quartile: 192-478 ng/mL) at hospital admission. In the daily serum monitoring with respect to the onset of symptoms, significantly higher hPASP levels were found in NP compared with AIP after day 2 (p < 0.001). In patients with NP, peak values of hPASP correlated significantly with the extent of pancreatic necroses measured by contrast-enhanced CT-scanning, whereas CRP did not. Six patients of the transplantation group had the same serum hPASP course as AIP, with almost normal values on the third postoperative day. One patient had elevated levels throughout the observation period. This patient suffered from necrotizing graft pancreatitis, confirmed by relaparotomy, and died because of subsequent septic complications.
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Authors | S W Schmid, W Uhl, A Steinle, B Rau, C Seiler, M W Büchler |
Journal | International journal of pancreatology : official journal of the International Association of Pancreatology
(Int J Pancreatol)
Vol. 19
Issue 3
Pg. 165-70
(Jun 1996)
ISSN: 0169-4197 [Print] United States |
PMID | 8807361
(Publication Type: Journal Article)
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Chemical References |
- Antigens, Neoplasm
- Biomarkers
- pancreas-specific antigen
- C-Reactive Protein
- Amylases
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Topics |
- Acute Disease
- Adult
- Aged
- Aged, 80 and over
- Amylases
(blood)
- Antigens, Neoplasm
(analysis)
- Biomarkers
- C-Reactive Protein
(analysis)
- Diabetes Mellitus, Type 1
(surgery)
- Female
- Humans
- Kidney Failure, Chronic
(surgery)
- Kidney Transplantation
- Male
- Middle Aged
- Necrosis
- Pancreas Transplantation
- Pancreatitis
(blood, diagnosis, pathology)
- Prognosis
- Prospective Studies
- Sensitivity and Specificity
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