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Significance of serum laminin P1 values in patients with transitional cell carcinoma of the bladder.

AbstractOBJECTIVES:
The goal of this study was to investigate the relation between serum laminin P1 expression and the grade, stage, size, and multiplicity of the tumors to elucidate the potential role of laminin as a diagnostic and prognostic factor in transitional cell carcinoma (TCC) of the bladder.
METHODS:
Serum concentration of laminin P1 was measured by radioimmunoassay in 38 patients with TCC of the bladder and compared with the serum laminin P1 values obtained from 34 healthy control subjects. Patients were grouped according to their tumor stage, grade, size, and multiplicity to compare the serum laminin P1 values.
RESULTS:
The mean serum laminin P1 level in the patient group was statistically higher than the controls (P = 1.3 x 10(-8); with the destruction of basement membrane (stages pT1 or greater), a significant increase in the serum value was observed (P = 0.00023). Laminin level was found to be positively related to the tumor size and number; however, no correlation was observed with the grade. In tumors invading the lamina propria and beyond, the sensitivity of laminin P1 was 78.9% and specificity was 97.1%. The positive and negative predictive values of laminin P1 were 93.7% and 89.5%, respectively. The patients whose serum laminin P1 levels were above the upper limit of normal (1.6863 U/mL) were found to have a higher recurrence rate (72%) than the patients who had lower serum values in the control cystoscopies performed 3 months after the first admission (P < 0.01).
CONCLUSIONS:
Serum laminin P1 seems to be a valuable adjunctive marker to predict tumor invasion and recurrence. This warrants further research.
AuthorsU Mungan, G Kirkali, I Celebi, Z Kirkali
JournalUrology (Urology) Vol. 48 Issue 3 Pg. 496-500 (Sep 1996) ISSN: 0090-4295 [Print] United States
PMID8804512 (Publication Type: Clinical Trial, Journal Article)
Chemical References
  • Laminin
  • Peptide Fragments
  • laminin P1
Topics
  • Aged
  • Aged, 80 and over
  • Carcinoma, Transitional Cell (blood, pathology)
  • Female
  • Follow-Up Studies
  • Humans
  • Laminin (blood)
  • Male
  • Middle Aged
  • Neoplasm Recurrence, Local (epidemiology)
  • Neoplasm Staging
  • Peptide Fragments (blood)
  • Prognosis
  • Urinary Bladder Neoplasms (blood, pathology)

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