Abstract |
We evaluated the effect of manipulation of nitric oxide (NO) synthesis on epileptiform discharges recorded from immobilized rats during intracerebroventricular injection of alpha-guanidinoglutaric acid (GGA), an endogenous convulsant and a NO synthase (NOS) inhibitor, alone or in combined with a NOS substrate, l-arginine (ARG). GGA alone, or combined with 50 mM ARG, resulted in prolonged electrographical seizures while co-injection of either 100 or 200 mM of ARG with GGA caused significantly protection. These data show that ARG inhibited epileptiform discharges in a dose-dependent fashion, suggesting that the discharges initiated by inhibition of NOS with the intrinsic convulsant GGA are abated by increasing the concentration of the NOS substrate ARG.
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Authors | H Habu, I Yokoi, H Kabuto, L J Willmore, A Mori |
Journal | Biochemistry and molecular biology international
(Biochem Mol Biol Int)
Vol. 39
Issue 1
Pg. 87-95
(May 1996)
ISSN: 1039-9712 [Print] England |
PMID | 8799331
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Glutarates
- alpha-guanidinoglutaric acid
- Arginine
- Nitric Oxide Synthase
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Topics |
- Animals
- Arginine
- Electroencephalography
- Glutarates
- Male
- Nitric Oxide Synthase
(biosynthesis)
- Rats
- Rats, Sprague-Dawley
- Seizures
(chemically induced)
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