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Seizures induced by alpha-guanidinoglutaric acid, a nitric oxide synthase inhibitor, are controlled by L-arginine.

Abstract
We evaluated the effect of manipulation of nitric oxide (NO) synthesis on epileptiform discharges recorded from immobilized rats during intracerebroventricular injection of alpha-guanidinoglutaric acid (GGA), an endogenous convulsant and a NO synthase (NOS) inhibitor, alone or in combined with a NOS substrate, l-arginine (ARG). GGA alone, or combined with 50 mM ARG, resulted in prolonged electrographical seizures while co-injection of either 100 or 200 mM of ARG with GGA caused significantly protection. These data show that ARG inhibited epileptiform discharges in a dose-dependent fashion, suggesting that the discharges initiated by inhibition of NOS with the intrinsic convulsant GGA are abated by increasing the concentration of the NOS substrate ARG.
AuthorsH Habu, I Yokoi, H Kabuto, L J Willmore, A Mori
JournalBiochemistry and molecular biology international (Biochem Mol Biol Int) Vol. 39 Issue 1 Pg. 87-95 (May 1996) ISSN: 1039-9712 [Print] England
PMID8799331 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Glutarates
  • alpha-guanidinoglutaric acid
  • Arginine
  • Nitric Oxide Synthase
Topics
  • Animals
  • Arginine
  • Electroencephalography
  • Glutarates
  • Male
  • Nitric Oxide Synthase (biosynthesis)
  • Rats
  • Rats, Sprague-Dawley
  • Seizures (chemically induced)

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