Abstract | BACKGROUND: The kinetics of para-[18F]fluorobenzylguanidine ([ 18F]PFBG) were investigated in a canine coronary artery occlusion model. METHODS AND RESULTS: Five dogs were imaged by positron emission tomography (PET) before and after complete surgical ligation of the left anterior descending coronary artery. PET studies included a 10-minute dynamic [13N]NH3 perfusion scan, followed 1 hour later by 3-hour dynamic [ 18F]PFBG scanning. [ 18F]PFBG and [13N]NH3 images demonstrated homogeneous myocardial uptake/perfusion before infarction. One hundred eighty minutes after [ 18F]PFBG administration, myocardial accumulation was decreased by 60% (day 2, 0.0065% +/- 0.0015% injected dose/ml) and 58% (day 16, 0.0069% +/- 0.003% injected dose/ml) compared with a similar myocardial region of interest from the preinfarction (0.016% +/- 0.005% injected dose/ml) study. Myocardial accumulation of [13N]NH3 at 9 minutes showed a 52% (day 2) and 7% (day 16) decrease compared with the preinfarction study. The accumulation of [ 18F]PFBG in the infarction was decreased significantly at 120 and 180 minutes on all postinfarction studies (p = 0.01). In three dogs a significant decrease in the myocardial norepinephrine concentration was documented in the area of infarction (237 +/- 94 ng/gm) versus the noninfarcted (1018 +/- 48 ng/gm) myocardium (p = 0.001). CONCLUSIONS: A decreased accumulation of [ 18F]PFBG was observed in the area of myocardial infarct in this canine model. The magnitude of the decrease in [ 18F]PFBG was larger than that seen with [13N]NH3 on day 16 after infarction, suggesting reperfusion and persistent sympathetic neuronal dysfunction.
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Authors | C R Berry, P K Garg, T R DeGrado, P Hellyer, W Weber, S Garg, B Hansen, M R Zalutsky, R E Coleman |
Journal | Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology
(J Nucl Cardiol)
1996 Mar-Apr
Vol. 3
Issue 2
Pg. 119-29
ISSN: 1071-3581 [Print] United States |
PMID | 8799237
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S.)
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Chemical References |
- 4-fluorobenzylguanidine
- Fluorobenzenes
- Guanidines
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Topics |
- Animals
- Coronary Disease
(diagnostic imaging)
- Dogs
- Fluorobenzenes
(pharmacokinetics)
- Guanidines
(pharmacokinetics)
- Heart
(diagnostic imaging)
- Myocardium
(metabolism)
- Tomography, Emission-Computed
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