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Oral magnetic particles (ferristene) as a contrast medium in abdominal magnetic resonance imaging.

AbstractRATIONALE AND OBJECTIVES:
In this phase III study, we evaluated the efficacy and safety of a negative contrast medium, ferristene (oral magnetic particles), among 277 patients undergoing magnetic resonance (MR) imaging of the abdomen.
METHODS:
Enhanced (800 ml ferristene) MR images were compared with unenhanced MR images in an intraindividual-patient control design. Adverse events were recorded. The examinations were performed on 1.5-T MR systems (T1- and T2-weighted sequences).
RESULTS:
Ferristene increased the diagnostic information in 50.9% of the patients, particularly in those with abdominal masses, lymphoma, or pancreatic disease. Distribution of ferristene in the stomach, duodenum, jejunum, and ileum was complete or sufficient in 70.5-85% of the studies. In 64% of the patients, we were confident in the MR findings after the use of ferristene, and ferristene disclosed additional findings in 22% of the patients. The incidence of adverse events was 9.0%, but only 3.6% of all patients experienced ferristene-related adverse events (e.g., nausea, vomiting). Most events were mild or moderate in intensity.
CONCLUSION:
Ferristene was well tolerated, and for 50% of the patients it added useful diagnostic information.
AuthorsT F Jacobsen, M Laniado, B E Van Beers, B Dupas, F P Boudghène, E Rummeny, T H Falke, P A Rinck, D MacVicar, B Lundby
JournalAcademic radiology (Acad Radiol) Vol. 3 Issue 7 Pg. 571-80 (Jul 1996) ISSN: 1076-6332 [Print] United States
PMID8796719 (Publication Type: Clinical Trial, Clinical Trial, Phase III, Journal Article, Multicenter Study)
Chemical References
  • Contrast Media
  • Ferric Compounds
  • ferristene
  • ferric oxide
Topics
  • Administration, Oral
  • Adolescent
  • Adult
  • Aged
  • Contrast Media (administration & dosage)
  • Digestive System (anatomy & histology)
  • Digestive System Diseases (pathology)
  • Female
  • Ferric Compounds (administration & dosage)
  • Humans
  • Magnetic Resonance Imaging (methods)
  • Male
  • Middle Aged

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