Abstract | OBJECTIVES: METHODS: Forty non-depressed patients with chronic tension type headache were included in a 32 week, double blind, placebo controlled, three-way crossover study. RESULTS: Thirty four patients completed the trial. Amitriptyline reduced area under the headache curve by 30% compared with placebo (P = 0.002), whereas citalopram had no significant effect (P = 0.68). Explanatory analyses showed that amitriptyline significantly reduced the duration of headache (P = 0.01), headache frequency (P = 0.01), and intake of analgesics (P = 0.02) but not headache intensity (P = 0.12). CONCLUSION:
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Authors | L Bendtsen, R Jensen, J Olesen |
Journal | Journal of neurology, neurosurgery, and psychiatry
(J Neurol Neurosurg Psychiatry)
Vol. 61
Issue 3
Pg. 285-90
(Sep 1996)
ISSN: 0022-3050 [Print] England |
PMID | 8795600
(Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antidepressive Agents, Tricyclic
- Placebos
- Serotonin Uptake Inhibitors
- Citalopram
- Amitriptyline
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Topics |
- Adolescent
- Adult
- Amitriptyline
(adverse effects, pharmacology, therapeutic use)
- Animals
- Antidepressive Agents, Tricyclic
(adverse effects, pharmacology, therapeutic use)
- Chronic Disease
- Citalopram
(adverse effects, pharmacology, therapeutic use)
- Cross-Over Studies
- Double-Blind Method
- Female
- Humans
- Male
- Middle Aged
- Patient Dropouts
- Placebos
- Selective Serotonin Reuptake Inhibitors
(adverse effects, pharmacology, therapeutic use)
- Tension-Type Headache
(drug therapy, prevention & control)
- Treatment Outcome
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