Abstract | OBJECTIVES: To evaluate platelet function in patients with coronary stents. DESIGN: A non-randomised control trial in 30 patients who had immediate implantation of Palmaz-Schatz coronary stents because of a suboptimal angioplasty result. All patients received a standardised anticoagulation regimen including intravenous heparin (activated partial thromboplastin time (APTT) 80 to 120 s), oral vitamin K antagonist (target international normalised ratio (INR) of 3.5), and 100 mg aspirin twice daily. Platelet surface expression of glycoprotein IIb-IIIa, activated fibrinogen receptor, and P-selectin as well as binding of von Willebrand factor and fibrinogen were determined by flow cytometry in peripheral venous blood samples collected before the intervention and then daily for 4 days after it. The results were compared with those in 30 patients undergoing elective coronary balloon angioplasty. SETTING: University hospital. RESULTS: CONCLUSIONS: The present study shows that current anticoagulation treatment is inefficient in suppressing platelet activation in patients with coronary stents and, therefore, might not be the best treatment for reducing the incidence of subacute stent thrombosis.
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Authors | M Gawaz, F J Neumann, I Ott, A May, S Rüdiger, A Schömig |
Journal | Heart (British Cardiac Society)
(Heart)
Vol. 76
Issue 2
Pg. 166-72
(Aug 1996)
ISSN: 1355-6037 [Print] England |
PMID | 8795482
(Publication Type: Clinical Trial, Comparative Study, Controlled Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antibodies, Monoclonal
- Platelet Membrane Glycoproteins
- Heparin
- Aspirin
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Angioplasty, Balloon, Coronary
- Antibodies, Monoclonal
- Aspirin
(therapeutic use)
- Blood Platelets
(metabolism)
- Coronary Disease
(metabolism, surgery, therapy)
- Female
- Flow Cytometry
- Heparin
(therapeutic use)
- Humans
- Male
- Middle Aged
- Platelet Activation
- Platelet Count
- Platelet Membrane Glycoproteins
(metabolism)
- Stents
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