Abstract | BACKGROUND: METHODS: H9 and peripheral blood mononuclear cells (PBMCs) were treated with reticulose before, during, and after infection with HIV-1 at various multiplicities. Treatment of cells with PNA significantly inhibited replication of HIV-1 as measured by synthesis of viral mRNA and p24 protein, reverse transcriptase activity, and syncitial cell formation. Exposure of cells to PNA under conditions that favor transfection of DNA, such as electroporation, markedly enhanced the inhibition of HIV replication. RESULTS: CONCLUSIONS: These results offer new tools for the study of immune functions and, moreover, open new approaches to the therapy of HIV infection and AIDS.
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Authors | S Z Hirschman, C W Chen |
Journal | Journal of investigative medicine : the official publication of the American Federation for Clinical Research
(J Investig Med)
Vol. 44
Issue 6
Pg. 347-51
(Aug 1996)
ISSN: 1081-5589 [Print] England |
PMID | 8795297
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antiviral Agents
- Chemokines
- Nucleic Acids
- Peptide Nucleic Acids
- Peptides
- RNA, Messenger
- Interferon-gamma
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Topics |
- Antiviral Agents
(pharmacology)
- Chemokines
(genetics)
- HIV-1
(drug effects, physiology)
- Humans
- Interferon-gamma
(biosynthesis, genetics)
- Nucleic Acids
(pharmacology)
- Peptide Nucleic Acids
- Peptides
(pharmacology)
- RNA, Messenger
(biosynthesis)
- Tumor Cells, Cultured
- Virus Replication
(drug effects)
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