Chelation in metal intoxication. XXXVIII: Effect of structurally different chelating agents in treatment of nickel intoxication in rat.

Abstract

Some structurally different chelating agents viz. alpha-mercapto-beta-(2-furyl) acrylic acid (MFA), alpha-mercapto-beta-(2-thienyl) acrylic acid (MTA), meso 2,3-dimercaptosuccinic acid (DMSA), 2,3-dimercaptopropane-1-sulfonate (DMPS), diethyl dithiocarbamate (DE-DTC), and N-benzyl-D-glucamine dithiocarbamate (NBG-DTC) were evaluated for their efficacy to mobilized nickel and reverse some nickel-induced biochemical alterations in experimental nickel intoxication. MFA, DMSA, and NBG-DTC appear more effective than their corresponding homologs, MTA, DMPS and DE-DTC, respectively, in enhancing urinary and fecal excretion of nickel and lowering tissue burden of nickel in nickel preexposed rats. These, particularly NBG-DTC, appear promising in the treatment of nickel (II) poisoning. However, there seems no definite relationship between the structure of the chelating agents examined and their ability to counteract the effects of nickel.

• Authors: S K Tandon, S Singh, V K Jain, S Prasad
• Journal: Fundamental and applied toxicology : official journal of the Society of Toxicology (Fundam Appl Toxicol) Vol. 31 Issue 2 Pg. 141-8 (Jun 1996) ISSN: 0272-0590 [Print] United States
• PMID: 8789779 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Acrylates
• Antidotes
• Chelating Agents
• Metals
• nickel sulfate
• 2-mercapto-3-furan-2-ylpropenoic acid
• Copper
• Nickel
• Ditiocarb
• Succimer
• dihydroxyethyldithiocarbamate
• Zinc

Topics

• Acrylates (pharmacology)
• Animals
• Antidotes (pharmacology)
• Brain (drug effects, metabolism)
• Chelating Agents (pharmacology)
• Copper (metabolism)
• Ditiocarb (analogs & derivatives, pharmacology)
• Kidney (drug effects, metabolism)
• Liver (drug effects, metabolism)
• Male
• Metals (metabolism)
• Nickel (toxicity)
• Rats
• Succimer (pharmacology)
• Zinc (metabolism)