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Role of cholecystokinin-B receptor in the maintenance of thermal hyperalgesia induced by unilateral constriction injury to the sciatic nerve in the rat.

Abstract
To gain a better understanding of the role of cholecystokinin (CCK)-B receptor in the maintenance of thermal hyperalgesia induced by unilateral constriction injury to the sciatic nerve in the rat, this study evaluated the effects of intrathecally administered YM022 (a CCK-B receptor antagonist) on thermal hyperalgesia. Drugs were administered intrathecally 1 or 5 weeks after the nerve injury (1 and 5 week study). In the 5 week study, but not the 1 week study, YM022 attenuated the level of thermal hyperalgesia in a dose-dependent manner. These data indicate that a CCK-B receptor antagonist attenuates the level of thermal hyperalgesia and this effect of a CCK-B receptor antagonist is time-dependent.
AuthorsT Yamamoto, N Nozaki-Taguchi
JournalNeuroscience letters (Neurosci Lett) Vol. 202 Issue 1-2 Pg. 89-92 (Dec 29 1995) ISSN: 0304-3940 [Print] Ireland
PMID8787838 (Publication Type: Journal Article)
Chemical References
  • Hormone Antagonists
  • Narcotic Antagonists
  • Receptors, Cholecystokinin
  • Receptors, Opioid
  • Benzodiazepines
  • YM 022
  • Naloxone
  • Dimethyl Sulfoxide
Topics
  • Animals
  • Behavior, Animal (physiology)
  • Benzodiazepines (pharmacology)
  • Dimethyl Sulfoxide
  • Hormone Antagonists (pharmacology)
  • Hot Temperature
  • Hyperalgesia (drug therapy, physiopathology)
  • Injections, Spinal
  • Male
  • Naloxone (pharmacology)
  • Narcotic Antagonists (pharmacology)
  • Nerve Compression Syndromes (drug therapy)
  • Rats
  • Rats, Sprague-Dawley
  • Receptors, Cholecystokinin (physiology)
  • Receptors, Opioid (drug effects)
  • Sciatic Nerve (injuries, physiopathology, ultrastructure)

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