An investigation of the activities of 3-hydroxykynureninase and kynurenine aminotransferase in the brain in Huntington's disease.

Abstract

Previous reports have indicated abnormalities in the concentrations of metabolites of the tryptophan/kynurenine pathway in the brain in Huntington's disease. These have included an increase in 3-hydroxykynurenine and both increases and decreases in kynurenic acid. The activities of two enzymes involved in the metabolism of these compounds, 3-hydroxykynureninase and kynurenine aminotransferase, have been determined in post mortem brain tissue taken from Huntington's disease patients and control subjects.

• Authors: S J Pearson, A Meldrum, G P Reynolds
• Journal: Journal of neural transmission. General section (J Neural Transm Gen Sect) Vol. 102 Issue 1 Pg. 67-73 ( 1995) Austria
• PMID: 8785025 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Transaminases
• glutamine - phenylpyruvate transaminase
• kynurenine-oxoglutarate transaminase
• Lyases

Topics

• Aged
• Alzheimer Disease (metabolism)
• Brain (enzymology)
• Female
• Frontal Lobe (metabolism)
• Humans
• Huntington Disease (metabolism)
• Lyases
• Male
• Middle Aged
• Transaminases (metabolism)