Abstract | BACKGROUND: MATERIALS AND METHODS: Pulmonary resistance, the release of thromboxane (TX) and the expression of COX-2 mRNA were measured in isolated blood-free perfused rat lungs exposed to LPS. RESULTS: CONCLUSIONS: LPS elicits the following biochemical and functional changes in rat lungs: (i) induction of COX-2; (ii) formation of prostaglandins and TX; (iii) activation of the TX receptor on airway smooth muscle cells; (iv) constriction of terminal bronchioles; and (v) increased airway resistance. In contrast to LPS, the PAF-induced TX release is likely to depend on COX-1.
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Authors | S Uhlig, R Nüsing, A von Bethmann, R L Featherstone, T Klein, F Brasch, K M Müller, V Ullrich, A Wendel |
Journal | Molecular medicine (Cambridge, Mass.)
(Mol Med)
Vol. 2
Issue 3
Pg. 373-83
(May 1996)
ISSN: 1076-1551 [Print] England |
PMID | 8784790
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Cyclooxygenase 2 Inhibitors
- Cyclooxygenase Inhibitors
- DNA Primers
- Endotoxins
- Isoenzymes
- Lipopolysaccharides
- Lipoxygenase Inhibitors
- Platelet Activating Factor
- Prostaglandin Endoperoxides, Synthetic
- RNA, Messenger
- Vasoconstrictor Agents
- Thromboxane B2
- Thromboxane A2
- 6-Ketoprostaglandin F1 alpha
- 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid
- Cyclooxygenase 2
- Prostaglandin-Endoperoxide Synthases
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Topics |
- 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid
- 6-Ketoprostaglandin F1 alpha
(metabolism)
- Animals
- Bronchoconstriction
(drug effects)
- Cyclooxygenase 2
- Cyclooxygenase 2 Inhibitors
- Cyclooxygenase Inhibitors
(pharmacology)
- DNA Primers
- Endotoxins
(pharmacology)
- Female
- In Vitro Techniques
- Isoenzymes
(biosynthesis)
- Lipopolysaccharides
(pharmacology)
- Lipoxygenase Inhibitors
(pharmacology)
- Lung
(drug effects, physiology, ultrastructure)
- Microscopy, Electron, Scanning
- Platelet Activating Factor
(pharmacology)
- Polymerase Chain Reaction
- Prostaglandin Endoperoxides, Synthetic
(pharmacology)
- Prostaglandin-Endoperoxide Synthases
(biosynthesis)
- RNA, Messenger
(biosynthesis)
- Rats
- Rats, Wistar
- Salmonella
- Thromboxane A2
(analogs & derivatives, pharmacology)
- Thromboxane B2
(metabolism)
- Transcription, Genetic
(drug effects)
- Vasoconstrictor Agents
(pharmacology)
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