Abstract | BACKGROUND & AIMS: METHODS: One hundred forty patients with significant peptic ulcer hemorrhage and active arterial bleeding or a nonbleeding visible vessel were randomized to endoscopic injection with 1:100,000 adrenaline (70 patients; group 1) or to adrenaline plus 600-1000 IU of human thrombin (70 patients; group 2). The two groups were well matched for age, shock, hemoglobin concentration, comorbid disease, endoscopic findings, and consumption of nonsteroidal anti-inflammatory drugs. RESULTS: Fourteen patients from group 1 (20%) and 3 patients from group 2 (4.5%) rebled (P < 0.005). Seven patients from group 1 (10%) but no patients from group 2 died within 30 days of admission (P < 0.013). Patients from group 1 were administered a total of 297 units of blood compared with 219 units in group 2 (P < 0.041). CONCLUSIONS:
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Authors | A K Kubba, W Murphy, K R Palmer |
Journal | Gastroenterology
(Gastroenterology)
Vol. 111
Issue 3
Pg. 623-8
(Sep 1996)
ISSN: 0016-5085 [Print] United States |
PMID | 8780566
(Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial)
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Chemical References |
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Drug Therapy, Combination
- Epinephrine
(administration & dosage, therapeutic use)
- Female
- Hemostasis, Endoscopic
- Humans
- Injections
- Male
- Middle Aged
- Peptic Ulcer Hemorrhage
(therapy)
- Thrombin
(administration & dosage, therapeutic use)
- Treatment Outcome
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