Inositol treatment of obsessive-compulsive disorder.

Abstract

OBJECTIVE:

Earlier studies reported that inositol, a simple polyol second messenger precursor, was effective in controlled trials for patients with depression and panic. In this study its effectiveness in obsessive-compulsive disorder was investigated.

METHOD:

Thirteen patients with obsessive-compulsive disorder completed a double-blind, controlled crossover trial of 18 g/day of inositol or placebo for 6 weeks each.

RESULTS:

The subjects had significantly lower scores on the Yale-Brown Obsessive Compulsive Scale when taking inositol than when taking placebo.

CONCLUSIONS:

The authors conclude that inositol is effective in depression, panic, and obsessive-compulsive disorder, a spectrum of disorders responsive to selective serotonin reuptake inhibitors.

• Authors: M Fux, J Levine, A Aviv, R H Belmaker
• Journal: The American journal of psychiatry (Am J Psychiatry) Vol. 153 Issue 9 Pg. 1219-21 (Sep 1996) ISSN: 0002-953X [Print] United States
• PMID: 8780431 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)

Chemical References

• Placebos
• Inositol

Topics

• Adult
• Analysis of Variance
• Cross-Over Studies
• Double-Blind Method
• Female
• Humans
• Inositol (therapeutic use)
• Male
• Middle Aged
• Obsessive-Compulsive Disorder (drug therapy, psychology)
• Placebos
• Treatment Outcome