Clinical effect of etidronate disodium (EHDP) on heterotopic ossification following total hip arthroplasty.

Abstract

We investigated the status of the development of heterotopic ossification and compared the frequency of heterotopic ossification in the EHDP group with that in the untreated (control) group to evaluate the efficacy and safety of EHDP. Seventy-seven patients who had undergone total hip arthroplasty or femoral head prosthesis for the treatment of osteoarthritis and femoral neck fracture were enrolled in the study. Heterotopic ossification surrounding the hip joint was evaluated according to the roentgenographic classification. In the control group, heterotopic ossification was found in 10 patients (20%) during the period, while in the EHDP group, it was found in one patient (3.7%) during the treatment period after the operation. Gastrointestinal disorder, in one case only was a side effect observed during EHDP treatment. It was revealed that EHDP inhibits heterotopic ossification following total hip replacement in patients with osteoarthritis.

• Authors: Y Yutani, H Ohashi, N Nishimura, Y Yamano
• Journal: Osaka city medical journal (Osaka City Med J) Vol. 41 Issue 2 Pg. 63-73 (Dec 1995) ISSN: 0030-6096 [Print] Japan
• PMID: 8778647 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)

Chemical References

• Etidronic Acid

Topics

• Adult
• Aged
• Aged, 80 and over
• Etidronic Acid (therapeutic use)
• Female
• Hip Prosthesis (adverse effects)
• Humans
• Male
• Middle Aged
• Ossification, Heterotopic (prevention & control)