Effect of ondansetron on nausea and vomiting after middle ear surgery during general anaesthesia.

Abstract

The efficacy of ondansetron 4 mg and 8 mg was compared with placebo in the reduction of postoperative nausea, retching and vomiting (PONV) after middle ear surgery during general anaesthesia, in 75 patients, in a double-blind and randomized study. Both doses of ondansetron were predictors for a decrease in PONV and the number of doses of rescue antiemetic needed per patient (droperidol: from 0.72 in the placebo group to 0.32 in both the 4-mg and 8-mg groups). No reduction in PONV was observed in patients with a history of motion sickness, whereas in patients without a history of motion sickness, ondansetron reduced both the proportion of patients suffering from PONV from 53% to 20% (P < 0.05) and of those needing droperidol from 53% to 17% (P < 0.05).

• Authors: P Honkavaara
• Journal: British journal of anaesthesia (Br J Anaesth) Vol. 76 Issue 2 Pg. 316-8 (Feb 1996) ISSN: 0007-0912 [Print] England
• PMID: 8777119 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)

Chemical References

• Antiemetics
• Ondansetron

Topics

• Adolescent
• Adult
• Anesthesia, General
• Antiemetics (administration & dosage, therapeutic use)
• Double-Blind Method
• Ear, Middle (surgery)
• Female
• Humans
• Male
• Middle Aged
• Nausea (prevention & control)
• Ondansetron (administration & dosage, therapeutic use)
• Postoperative Complications (prevention & control)
• Premedication
• Vomiting (prevention & control)