Abstract |
In this study we investigated the interactions between volume changes (body weight), plasma atrial natriuretic peptide (pANP) and ambulatory blood pressure (BP) in 10 patients with end-stage renal disease undergoing regular hemodialysis (HD) treatment three times weekly. Most patients retained their diurnal BP variation when their BP was adequately controlled. Interdialytic weight gain was 1.3 +/- 0.2 kg and the day-time systolic BP increased 12.5 +/- 4.8 mm Hg on the second interdialytic day. pANP did not correlate (r = -0.07, p = 0.85) with this BP elevation, but there was a fairly strong positive correlation (r = 0.61, p = 0.06) between interdialytic weight gain and systolic BP. The mean pANP level decreased from 149.7 +/- 18.2 to 117 +/- 0.1 ng/l during HD and continued its decrease to 83 +/- 12.2 ng/l at 20 h after an HD session. The total decrease from 149.7 +/- 18.2 to 83 +/- 12.2 ng/l was statistically significant (p = 0.001). Since the lowest pANP value was found 20 h after completion of the dialysis session, body weight is a more reliable indicator of volume reduction during HD than pANP. The results indicate that in HD patients weight gain between two dialysis sessions increases the day-time systolic BP but not the diastolic BP. Diurnal BP variation is maintained as long as BP is adequately controlled either by volume control or by drug treatment.
|
Authors | S Ojanen, K Pietilä, A Pasternack |
Journal | Nephron
(Nephron)
Vol. 73
Issue 2
Pg. 174-8
( 1996)
ISSN: 1660-8151 [Print] Switzerland |
PMID | 8773340
(Publication Type: Clinical Trial, Journal Article)
|
Chemical References |
- Atrial Natriuretic Factor
|
Topics |
- Adult
- Aged
- Atrial Natriuretic Factor
(blood)
- Blood Pressure
(physiology)
- Blood Pressure Monitoring, Ambulatory
- Body Weight
(physiology)
- Circadian Rhythm
(physiology)
- Female
- Humans
- Kidney Failure, Chronic
(blood, physiopathology)
- Kidney Transplantation
(physiology)
- Male
- Middle Aged
- Renal Dialysis
|