[Fansidar in the treatment of toxoplasmosis].

Abstract

Toxoplasmosis chorioretinitis is the most frequent posterior uveitis. Different treatment modes are used for its therapy. Classical is the combination of 50 mg of pyrimethamine with 4 g of sulphadiazine and corticosteroids. In this study the results of treatment with lower doses of pyrimethamine together with long-acting sulphonamide are reported. Twelve patients were treated with Fansidar, combination of 25 mg of pyrimethamine and 500 mg sulphadoxine. The treatment consisted of a loading dose of two tablets of Fansidar, followed by one tablet a day. Prednisone 0.5 mg/kg/day was added and gradually tapered off. Patients were treated for 28 days on average (range 21-50 days). In 83% of patients the scar was considerably smaller than original lesion (on average the scar represented 25% of original lesion). Three months after the treatment the visual acuity was 6/9 or better in 83% of patients. No side-effects of the treatment were observed. Lower doses of pyrimethamine with suphadoxine in an easy once a day treatment regime could be an alternative and cost-effective therapy for ocular toxoplasmosis.

• Authors: K Michalová, E Ríhová, M Havlíková
• Journal: Ceska a slovenska oftalmologie : casopis Ceske oftalmologicke spolecnosti a Slovenske oftalmologicke spolecnosti (Cesk Slov Oftalmol) Vol. 52 Issue 3 Pg. 173-8 (Jul 1996) ISSN: 1211-9059 [Print] Czech Republic
• Vernacular Title: Fansidar v lécbĕ ocní toxoplazmózy.
• PMID: 8768475 (Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antiprotozoal Agents
• Drug Combinations
• fanasil, pyrimethamine drug combination
• Sulfadoxine
• Pyrimethamine

Topics

• Adolescent
• Adult
• Antiprotozoal Agents (therapeutic use)
• Drug Combinations
• Humans
• Middle Aged
• Pyrimethamine (therapeutic use)
• Retrospective Studies
• Sulfadoxine (therapeutic use)
• Toxoplasmosis, Ocular (drug therapy)