| Abstract | Toxoplasmosis chorioretinitis is the most frequent posterior uveitis. Different treatment modes are used for its therapy. Classical is the combination of 50 mg of pyrimethamine with 4 g of sulphadiazine and corticosteroids. In this study the results of treatment with lower doses of pyrimethamine together with long-acting sulphonamide are reported. Twelve patients were treated with Fansidar, combination of 25 mg of pyrimethamine and 500 mg sulphadoxine. The treatment consisted of a loading dose of two tablets of Fansidar, followed by one tablet a day. Prednisone 0.5 mg/kg/day was added and gradually tapered off. Patients were treated for 28 days on average (range 21-50 days). In 83% of patients the scar was considerably smaller than original lesion (on average the scar represented 25% of original lesion). Three months after the treatment the visual acuity was 6/9 or better in 83% of patients. No side-effects of the treatment were observed. Lower doses of pyrimethamine with suphadoxine in an easy once a day treatment regime could be an alternative and cost-effective therapy for ocular toxoplasmosis. |
| Authors | K Michalová, E Ríhová, M Havlíková
(Affiliation: I. ocní klinika 1. LF UK, Praha.)
|
| Journal | Ceská a slovenská oftalmologie : casopis Ceské oftalmologické spolecnosti a Slovenské oftalmologické spolecnosti
(Cesk Slov Oftalmol)
Vol. 52
Issue 3
Pg. 173-8
(Jul 1996)
ISSN: 1211-9059 CZECHOSLOVAKIA |
| Vernacular Title | Fansidar v lécbĕ ocní toxoplazmózy. |
| PMID | 8768475
(Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't)
|
| Chemical References |
- Antiprotozoal Agents
- Drug Combinations
- Sulfadoxine
- sulfadoxine-pyrimethamine
- Pyrimethamine
|
| Topics |
- Adolescent
- Adult
- Antiprotozoal Agents
(therapeutic use)
- Drug Combinations
- Humans
- Middle Aged
- Pyrimethamine
(therapeutic use)
- Retrospective Studies
- Sulfadoxine
(therapeutic use)
- Toxoplasmosis, Ocular
(drug therapy)
|
