Antiviral activity of lignans and their glycosides from Justicia procumbens.

Abstract

Ten antiviral lignans, seven known (justicidins A, B, C and D, diphyllin, diphyllin apioside and diphyllin apioside-5-acetate) and three new compounds, justicidinosides A (justicidin C 6'-O-glucoside), B (justicidin A 6'-O-glucoside) and C (justicidin B 6'-O-glucoside), were isolated from a methanolic extract of the aerial parts of Justicia procumbens var. leucantha. Justicidins A and B, diphyllin, diphyllin apioside and diphyllin apioside-5-acetate showed strong antiviral activity (the MIC were less than 0.25 microgram ml-1, respectively) against vesicular stomatitis virus and low cytotoxicity (the MTC were larger than 31 micrograms ml-1, respectively) against cultured rabbit lung cells (RL-33).

• Authors: J Asano, K Chiba, M Tada, T Yoshii
• Journal: Phytochemistry (Phytochemistry) Vol. 42 Issue 3 Pg. 713-7 (Jun 1996) ISSN: 0031-9422 [Print] England
• PMID: 8768323 (Publication Type: Journal Article)

Chemical References

• Antiviral Agents
• Benzodioxoles
• Dioxolanes
• Glycosides
• Lignans
• diphyllin

Topics

• Animals
• Antiviral Agents (chemistry, isolation & purification, pharmacology)
• Benzodioxoles
• Cell Line
• Cell Survival (drug effects)
• China
• Dioxolanes (chemistry, isolation & purification, pharmacology)
• Glycosides (chemistry, isolation & purification, pharmacology)
• Lignans (chemistry, isolation & purification, pharmacology)
• Lung
• Molecular Structure
• Plants, Medicinal
• Rabbits
• Spectrometry, Mass, Fast Atom Bombardment
• Vesicular stomatitis Indiana virus (drug effects)