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[Oral testing for sulfite asthma].

AbstractAIM OF THE STUDY:
Patients with asthma may develop bronchoconstriction after ingestion of sulfites. We studied the sensitivity and specificity of an oral provocation challenge with metabisulfite to detect a sulfite-sensitive asthma.
METHODS:
We performed an oral dose-response metabisulfite challenge in 44 patients with a history of sulfite-sensitive asthma, 27 patients with asthma but without a history of sulfite sensitivity, and 8 control subjects without asthma. Metabisulfite was administered in capsules in a single-blind manner. Airway response was assessed by FEV decline, measured 30' after each dose.
RESULTS:
Thirty-nine percent of patients with a history of sulfite-sensitive asthma demonstrated a significant bronchoconstriction after ingestion of metabisulfite, whereas patients without an appropriate history and control subjects did not respond to the challenge.
CONCLUSIONS:
The oral metabisulfite challenge exhibits a high specificity (100%) but low sensitivity of about 40%. Nonetheless, taking into account the uncertainties in the patients' history of sulfite-sensitive asthma, the oral metabisulfite challenge as performed by us is a useful method for the diagnosis of sulfite sensitive asthma.
AuthorsH Hein, D Kirsten, R A Jörres, H Magnussen
JournalPneumologie (Stuttgart, Germany) (Pneumologie) Vol. 50 Issue 6 Pg. 394-8 (Jun 1996) ISSN: 0934-8387 [Print] Germany
Vernacular TitleDie orale Testung auf Sulfitasthma.
PMID8766371 (Publication Type: English Abstract, Journal Article)
Chemical References
  • Sulfites
  • metabisulfite
Topics
  • Administration, Oral
  • Adult
  • Airway Resistance (drug effects)
  • Asthma (diagnosis, immunology)
  • Female
  • Forced Expiratory Volume (drug effects)
  • Humans
  • Male
  • Middle Aged
  • Respiratory Hypersensitivity (diagnosis, immunology)
  • Single-Blind Method
  • Sulfites (adverse effects, immunology)
  • Vital Capacity (drug effects)

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