HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Urtica dioica agglutinin, a V beta 8.3-specific superantigen, prevents the development of the systemic lupus erythematosus-like pathology of MRL lpr/lpr mice.

Abstract
The V beta 8.3-specific superantigenic lectin Urtica dioica agglutinin (UDA) was used to delete the V beta 8.3+ T cells in MRL lpr/lpr mice. In contrast to the systemic lupus erythematosus-like pathology which progresses with age in the phosphate-buffered saline-injected MRL lpr/lpr controls, UDA-treated animals did not develop overt clinical signs of lupus and nephritis. The pathogenic T cell clones thus reside within the V beta 8.3+ T cell population, which includes an expanded T cell clone described previously. Finally, UDA alters the production of autoantibodies in a sex-dependent manner.
AuthorsP Musette, A Galelli, H Chabre, P Callard, W Peumans, P Truffa-Bachi, P Kourilsky, G Gachelin
JournalEuropean journal of immunology (Eur J Immunol) Vol. 26 Issue 8 Pg. 1707-11 (Aug 1996) ISSN: 0014-2980 [Print] Germany
PMID8765010 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Epitopes
  • Lectins
  • Plant Lectins
  • Receptors, Antigen, T-Cell, alpha-beta
  • Superantigens
  • stinging nettle lectin
Topics
  • Animals
  • Epitopes (administration & dosage, therapeutic use)
  • Female
  • Injections, Intravenous
  • Lectins (administration & dosage, therapeutic use)
  • Lupus Erythematosus, Systemic (immunology, pathology, prevention & control)
  • Male
  • Mice
  • Mice, Mutant Strains
  • Plant Lectins
  • Receptors, Antigen, T-Cell, alpha-beta (immunology)
  • Superantigens (administration & dosage, therapeutic use)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: