Abstract |
The V beta 8.3-specific superantigenic lectin Urtica dioica agglutinin (UDA) was used to delete the V beta 8.3+ T cells in MRL lpr/lpr mice. In contrast to the systemic lupus erythematosus-like pathology which progresses with age in the phosphate-buffered saline-injected MRL lpr/lpr controls, UDA-treated animals did not develop overt clinical signs of lupus and nephritis. The pathogenic T cell clones thus reside within the V beta 8.3+ T cell population, which includes an expanded T cell clone described previously. Finally, UDA alters the production of autoantibodies in a sex-dependent manner.
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Authors | P Musette, A Galelli, H Chabre, P Callard, W Peumans, P Truffa-Bachi, P Kourilsky, G Gachelin |
Journal | European journal of immunology
(Eur J Immunol)
Vol. 26
Issue 8
Pg. 1707-11
(Aug 1996)
ISSN: 0014-2980 [Print] Germany |
PMID | 8765010
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Epitopes
- Lectins
- Plant Lectins
- Receptors, Antigen, T-Cell, alpha-beta
- Superantigens
- stinging nettle lectin
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Topics |
- Animals
- Epitopes
(administration & dosage, therapeutic use)
- Female
- Injections, Intravenous
- Lectins
(administration & dosage, therapeutic use)
- Lupus Erythematosus, Systemic
(immunology, pathology, prevention & control)
- Male
- Mice
- Mice, Mutant Strains
- Plant Lectins
- Receptors, Antigen, T-Cell, alpha-beta
(immunology)
- Superantigens
(administration & dosage, therapeutic use)
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