Increased interleukin-10 mRNA expression in tumor-bearing or persistently lymphocytotic animals infected with bovine leukemia virus.

Abstract

Interleukin-10 (IL-10), produced by Th2 helper T cells, B cells, and macrophages, can inhibit cytokine production by Th1 cells and enhance B-cell proliferation and differentiation. Here, we show that peripheral blood mononuclear cells (PBMCs) from bovine leukemia virus-infected animals with late-stage disease express considerably more IL-10 mRNA than animals that are not infected or that are in the early stages of disease. In contrast, the quantities of type 1 cytokines, IL-2 and gamma interferon, decrease with disease progression. In addition, we observed that IL-10 is expressed principally by monocytes/macrophages, not B lymphocytes, in persistently lymphocytotic animals. This observation supports a role for monocytes/macrophages in progression of bovine leukemia virus infection and, of importance, indicates that proliferating B cells are not the source of IL-10 expression. These findings suggest that IL-10 produced by monocytes/macrophages may influence the progression of bovine leukosis in animals that develop persistent lymphocytosis of B cells or B-cell lymphosarcoma.

• Authors: D Pyeon, K L O'Reilly, G A Splitter
• Journal: Journal of virology (J Virol) Vol. 70 Issue 8 Pg. 5706-10 (Aug 1996) ISSN: 0022-538X [Print] United States
• PMID: 8764093 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• RNA, Messenger
• Interleukin-10

Topics

• Animals
• Cattle
• Enzootic Bovine Leukosis (blood, immunology)
• Interleukin-10 (biosynthesis)
• Leukemia Virus, Bovine
• Leukocytes, Mononuclear (immunology)
• RNA, Messenger (biosynthesis)