Abstract |
Interleukin-10 (IL-10), produced by Th2 helper T cells, B cells, and macrophages, can inhibit cytokine production by Th1 cells and enhance B-cell proliferation and differentiation. Here, we show that peripheral blood mononuclear cells (PBMCs) from bovine leukemia virus-infected animals with late-stage disease express considerably more IL-10 mRNA than animals that are not infected or that are in the early stages of disease. In contrast, the quantities of type 1 cytokines, IL-2 and gamma interferon, decrease with disease progression. In addition, we observed that IL-10 is expressed principally by monocytes/macrophages, not B lymphocytes, in persistently lymphocytotic animals. This observation supports a role for monocytes/macrophages in progression of bovine leukemia virus infection and, of importance, indicates that proliferating B cells are not the source of IL-10 expression. These findings suggest that IL-10 produced by monocytes/macrophages may influence the progression of bovine leukosis in animals that develop persistent lymphocytosis of B cells or B-cell lymphosarcoma.
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Authors | D Pyeon, K L O'Reilly, G A Splitter |
Journal | Journal of virology
(J Virol)
Vol. 70
Issue 8
Pg. 5706-10
(Aug 1996)
ISSN: 0022-538X [Print] United States |
PMID | 8764093
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- RNA, Messenger
- Interleukin-10
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Topics |
- Animals
- Cattle
- Enzootic Bovine Leukosis
(blood, immunology)
- Interleukin-10
(biosynthesis)
- Leukemia Virus, Bovine
- Leukocytes, Mononuclear
(immunology)
- RNA, Messenger
(biosynthesis)
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