Successful treatment of a patient with octreotide-resistant necrolytic migratory erythema.

Abstract

We report a patient with the glucagonoma syndrome and octreotide-resistant necrolytic migratory erythema (NME). The NME responded on two occasions to an intravenous infusion of essential fatty acids (EFA) and amino acids (AA). A deficit of serum EFA prior to treatment was corrected following the infusion, whilst plasma AA were low before and after treatment. These findings indicate that NME, in the glucagonoma syndrome, may respond to correction of the EFA deficit, and that NME may be a disease of EFA deficiency.

• Authors: A P Bewley, J S Ross, C B Bunker, R C Staughton
• Journal: The British journal of dermatology (Br J Dermatol) Vol. 134 Issue 6 Pg. 1101-4 (Jun 1996) ISSN: 0007-0963 [Print] England
• PMID: 8763433 (Publication Type: Case Reports, Journal Article)

Chemical References

• Amino Acids
• Fatty Acids, Essential
• Octreotide

Topics

• Amino Acids (blood)
• Drug Resistance, Neoplasm
• Erythema (blood, drug therapy, etiology)
• Fatty Acids, Essential (blood, therapeutic use)
• Glucagonoma (complications)
• Humans
• Male
• Middle Aged
• Octreotide (therapeutic use)
• Pancreatic Neoplasms (complications)
• Paraneoplastic Syndromes (blood, drug therapy)