Abstract | UNLABELLED: MATERIAL AND METHODS: There were 12 males and 8 females; the mean age was 19 years (range 12-51). The site of the tumor was the femoral neck (1 case), femoral diaphysis (2 cases), distal femur (12 cases), proximal tibia (4 cases), distal tibia (1 case), 3 were IIA and 17 IIB according to Enneking system. Conservative treatment was performed in 17 cases: there were 12 knee prostheses, 4 allografts and 1 knee arthrodesis with allograft. RESULTS: a) Surgical complications: Mechanical complications occurred in 10 patients. The function was preserved 8 times. In 2 patients the knee became stiff. An infection occurred in 3 patients: a conservative treatment was possible in 2 of them with a fair result. In the third case, an above-the-knee amputation had to be done. b) Functional results were studied according to Enneking rating. 14 arthroplasties (12 done as first surgical treatment and 2 after mechanical complication) had a 68, 19 score. c) Oncologic results: 8 patients were good respondents and 12 patients were bad respondents to chemotherapy according to Huvos grading. One local relapse was observed which could be treated by mean of a second chemotherapy and a prosthetic reconstruction. The patient is still alive and disease-free at 7 years (9 years after the diagnosis of the osteosarcoma). 5 patients had distant metastasis (lung, bones, and brain). One out of 5 was good respondent and 4 out of 5 are presently dead. Using Kaplan Meier statistical analysis, the overall survival wzs 76.8 per cent and the event-free survival was 67.4 per cent at 80 months. CONCLUSION: We preferred a simple prosthetic reconstruction without osseous sleeve or an intercalary allograft if possible: these procedures allow the patient very rapid autonomy to have despite a prolonged chemotherapy.
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Authors | S R Babin, P Simon, A Babin-Boilletot, J P Bellocq, L Marcellin, J C Dosch |
Journal | Revue de chirurgie orthopedique et reparatrice de l'appareil moteur
(Rev Chir Orthop Reparatrice Appar Mot)
Vol. 82
Issue 1
Pg. 14-21
( 1996)
ISSN: 0035-1040 [Print] France |
Vernacular Title | Ostéosarcome de haut grade de malignité du membre inférieur. Complications et résultats du traitement de 20 patients. |
PMID | 8762984
(Publication Type: Case Reports, English Abstract, Journal Article)
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Topics |
- Actuarial Analysis
- Adolescent
- Adult
- Bone Neoplasms
(pathology, therapy)
- Child
- Combined Modality Therapy
- Female
- Follow-Up Studies
- Humans
- Knee Prosthesis
(adverse effects)
- Male
- Middle Aged
- Neoplasm Recurrence, Local
- Neoplasm Staging
- Osteosarcoma
(pathology, therapy)
- Prognosis
- Reoperation
- Survival Rate
- Transplantation, Homologous
(adverse effects)
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