[Turner syndrome: spontaneous growth of stature, weight increase and accelerated bone maturation].

Abstract

BACKGROUND:

Since growth hormone is effective in increasing the height of girls with Turner's syndrome, it is important to dispose of growth and bone maturation curves in a large number of untreated patients.

POPULATION AND METHODS:

Data on growth and bone maturation were collected from 160 patients with Turner's syndrome (50 have reached final height), born 1965-1991, untreated with growth hormone or anabolic steroids. X monosomy was found in half of the patients, mosaicism or X abnormality was present in the other half. Spontaneous puberty occurred in 25% (n = 25) of patients older than 13 years, 38 patients received estrogen after 13 years. Final heights were compared to predicted height according to Lyon's method.

RESULTS:

Forty-five percent of patients were small for date. Height velocity decreased from 2 years of age and decreased faster during adolescence, when gonadal dysgenesis occurred. Bone maturation velocity decreased also during adolescence. Excessive weight appeared after the age of 5 years. Patients with partial deletion of the long arm of X (n = 6) were taller than the other girls (n = 44) (mean +/- DS) 152.5 +/- 3.1 cm, range 150-158 cm versus 142.5 +/- 4.9 cm, 130-150 cm (P < 0.0001). Final height was not modified by spontaneous puberty. Final height was correlated with birth weight (r = 0.7), maternal height (r = 0.5) and mid parental height (r = 0.5). Finally, the Lyon's method for predicted final height seemed to be suitable for this population, (r = 0.8, P < 0.001).

CONCLUSION:

Appropriate growth curve is an essential clinical tool in evaluating treatment aimed at increasing final stature in patients with Turner's syndrome.

• Authors: S Cabrol, C Saab, M Gourmelen, M C Raux-Demay, Y Le Bouc
• Journal: Archives de pediatrie : organe officiel de la Societe francaise de pediatrie (Arch Pediatr) Vol. 3 Issue 4 Pg. 313-8 (Apr 1996) ISSN: 0929-693X [Print] France
• Vernacular Title: Syndrome de Turner: croissance staturopondérale et maturation osseuse spontanées.
• PMID: 8762950 (Publication Type: English Abstract, Journal Article)

Topics

• Adolescent
• Body Height
• Body Weight
• Bone Development
• Chromosome Deletion
• Chromosomes
• Female
• Fetal Growth Retardation (physiopathology)
• Follow-Up Studies
• Growth
• Humans
• Pregnancy
• Turner Syndrome (genetics, physiopathology)