[Prevention of postoperative nausea and vomiting by lorazepam].

Abstract

This study was carried out to assess the efficacy of oral lorazepam on postoperative nausea and vomiting in patients undergoing thyroid surgery. Twenty-six patients were randomly assigned to two groups, and receiving orally, one hour before induction of anaesthesia, either 2.5 mg of lorazepam (n = 13) or a placebo (n = 13). Lorazepam reduced the incidence and especially the intensity of nausea. The incidence of vomiting in the lorazepam group was significantly lower than in the placebo group (14.5% vs 45%). The use of lorazepam for premedication thus reduces the incidence of postoperative nausea and vomiting. The advantages of this benzodiazepine are its ease of use, low cost and very low incidence of side effects.

• Authors: M Laraki, M el Mouknia, A Bouaguad, B Idali, M Benaguida
• Journal: Cahiers d'anesthesiologie (Cah Anesthesiol) Vol. 44 Issue 2 Pg. 159-62 ( 1996) ISSN: 0007-9685 [Print] France
• Vernacular Title: Prévention des nausées et vomissements postopératoires par le lorazépam.
• PMID: 8760643 (Publication Type: Clinical Trial, English Abstract, Journal Article, Randomized Controlled Trial)

Chemical References

• Anti-Anxiety Agents
• Placebos
• Lorazepam

Topics

• Adult
• Anti-Anxiety Agents (therapeutic use)
• Humans
• Lorazepam (therapeutic use)
• Nausea (prevention & control)
• Placebos
• Postoperative Complications (prevention & control)
• Preanesthetic Medication
• Vomiting (prevention & control)