Direct radioiodination of metabolic 8-hydroxy-quinolyl-glucuronide, as a potential anti-cancer drug.

Abstract

8-Hydroxy-quinolyl-glucuronide (8-HOQ-Glu) can be deglucuronidated by the beta-glucoronidase enzyme, which has an activity that is considerably high in certain kinds of cancer cell. Owing to this enzyme activity, 8-HOQ-Glu can be considered as a potential anti-cancer drug. The combination of the radiotoxicity known of 125I nuclide with the cytotoxicity of 8-hydroxy-quinoline (8-HOQ) and particularly the selective carrying of 125I into the cancer cells is the principal aim of this study. As a first step, the metabolic 8-HOQ-Glu was extracted from the urine of rabbits treated with 8-HOQ directly radioiodinated using the iodogen method. The results showed that the radioiodination was successfully realized, and its yield was found to be about 90-95%.

• Authors: T Unak, P Unak
• Journal: Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine (Appl Radiat Isot) Vol. 47 Issue 7 Pg. 645-7 (Jul 1996) ISSN: 0969-8043 [Print] England
• PMID: 8759157 (Publication Type: Journal Article)

Chemical References

• Antineoplastic Agents
• Hydroxyquinolines
• Iodine Radioisotopes
• 8-hydroxyquinoline glucuronide

Topics

• Animals
• Antineoplastic Agents (chemical synthesis, chemistry, urine)
• Hydroxyquinolines (chemical synthesis, chemistry, urine)
• Iodine Radioisotopes (chemistry)
• Isotope Labeling (methods)
• Rabbits