Abstract | OBJECTIVE: METHODS: RESULTS: Histological changes showed that the cell nucleus to cell plasma ratio decreased, the nuclear mitoses reduced and the nuclear shape varied from stick to circular, indicating a tendency of cancer cells towards better differentiation. For pre-menopausal patients, follicle-stimulating hormone (FSH) increased, the concentration of ER either rose or went down while PR increased. For post-menopausal patients, FSH decreased, the concentrations of ER and PR were mainly on the increase. CONCLUSION:
Tamoxifen was effective in treating patients with endometrial cancer. For pre-menopausal patients, it acted as an antioestrogen. For post-menopausal patients, it acted as a weak oestrogen.
|
Authors | H Sun, X Zhang |
Journal | Zhonghua fu chan ke za zhi
(Zhonghua Fu Chan Ke Za Zhi)
Vol. 31
Issue 2
Pg. 83-5
(Feb 1996)
ISSN: 0529-567X [Print] China |
PMID | 8758799
(Publication Type: Comparative Study, English Abstract, Journal Article)
|
Chemical References |
- Antineoplastic Agents, Hormonal
- Receptors, Estrogen
- Receptors, Progesterone
- Tamoxifen
- Estradiol
|
Topics |
- Antineoplastic Agents, Hormonal
(therapeutic use)
- Endometrial Neoplasms
(drug therapy, metabolism, pathology)
- Estradiol
(metabolism)
- Female
- Humans
- Menopause
- Prospective Studies
- Receptors, Estrogen
(metabolism)
- Receptors, Progesterone
(metabolism)
- Tamoxifen
(therapeutic use)
|