[The effect of nimodipine and papaverine on delayed cerebral vasospasm in dogs].

Abstract

OBJECTIVE:

To evaluate the effect of nimodipine and papaverine (Pap) on the spastic arteries with delayed cerebral vasospasm (DCVS) in dogs.

METHODS:

A model of DCVS in dogs was induced by the cisterna magna injections of fresh autologous blood twice. The diameter of the basilar arteries with and without DCVS was measured with the aid of a JVC operative microes cope in vivo after nimodipine and Pap were directly placed around the arteries.

RESULTS:

The dilation of the basilar arteries was obviously induced by application of nimodipine and Pap in the dogs without DCVS no dilation was induced by application of nimodipine and slight dilation by application of Pap but in those with DCVS.

CONCLUSION:

The cerebral blood flow is improved by the effect of nimodipine on non-spastic arteries. Pap has been found to reverse slightly the narrowing of the basilar arteries with DCVS and to dilate the arteries without DCVS, but the vasodilation effect is transient.

• Authors: F Liu, D Liu, M Rao
• Journal: Zhonghua yi xue za zhi (Zhonghua Yi Xue Za Zhi) Vol. 76 Issue 2 Pg. 132-4 (Feb 1996) ISSN: 0376-2491 [Print] China
• PMID: 8758447 (Publication Type: English Abstract, Journal Article)

Chemical References

• Vasodilator Agents
• Nimodipine
• Papaverine

Topics

• Animals
• Basilar Artery (drug effects)
• Cerebrovascular Circulation (drug effects)
• Dogs
• Female
• Ischemic Attack, Transient (physiopathology)
• Male
• Nimodipine (pharmacology)
• Papaverine (pharmacology)
• Vasodilator Agents (pharmacology)