Coexistence of familial antiphospholipid syndrome and factor V Leiden: impact on thrombotic diathesis.

Abstract

Two young siblings who presented with an unusual recurrent severe thromboembolic phenomenon were found to have familial anti-phospholipid syndrome and were heterozygous for the factor V R506Q mutation. The coexistence of hereditary and acquired APC-resistance may explain the severity of thromboembolism.

• Authors: B Brenner, S L Vulfsons, N Lanir, M Nahir
• Journal: British journal of haematology (Br J Haematol) Vol. 94 Issue 1 Pg. 166-7 (Jul 1996) ISSN: 0007-1048 [Print] England
• PMID: 8757529 (Publication Type: Case Reports, Journal Article)

Chemical References

• Anticoagulants
• Protein C
• Factor V

Topics

• Abortion, Spontaneous (etiology)
• Adult
• Anticoagulants (therapeutic use)
• Antiphospholipid Syndrome (blood, complications, genetics)
• Bone Marrow (blood supply)
• Factor V (genetics)
• Female
• Femoral Artery
• Fetal Death
• Humans
• Pregnancy
• Pregnancy Complications, Cardiovascular (etiology)
• Protein C (antagonists & inhibitors)
• Thromboembolism (blood, etiology, genetics)
• Thrombosis (etiology)