[Results of tests with clomiphene and choriogonadotropin in men with oligozoospermia treated with longterm antiestrogens].

Abstract

The evaluation was made of the response to testosterone and oestradiol in the test (50 mg twice daily for 10 days) and HCG test (6000 units of Biogonadyl through 2 days) performed on 21 normospermic (fertile) males and on patients with normogonadotropic, idiopathic oligozoospermia, positively (12 patients) or negatively (24 males) reacting to the longterm Clostilbegyt treatment (50 mg daily for 240 days). It was shown that patients with oligozoospermia who do not react with an increase of spermatozoa during the longterm antioestrogen treatment had higher response of oestradiol in the dynamic test (+ 118.9%) than the normospermic males (+ 60.8%) or the oligozoospermic who showed positive semenologic response to the treatment (+ 58.8%). The similar reaction of oestradiol was shown in the HCG stimulation. In the hiperoestrogenism phenomenon the authors noticed the cause of lack of positive semenologic effects of the longterm antioestrogen treatment.

• Authors: M Medraś, L Terpiłowski, D Kiełkiewicz, J Winowski, G Ziotas
• Journal: Polski tygodnik lekarski (Warsaw, Poland : 1960) (Pol Tyg Lek) Vol. 51 Issue 6-9 Pg. 73-4 (Feb 1996) ISSN: 0032-3756 [Print] Poland
• Vernacular Title: Wyniki testu z klomifenem i choriogonadotropina u mezczyzn z oligozoospermia przewlekle leczonych przeciwestrogenowo.
• PMID: 8756734 (Publication Type: Clinical Trial, Controlled Clinical Trial, English Abstract, Journal Article)

Chemical References

• Chorionic Gonadotropin
• Estrogen Antagonists
• Clomiphene

Topics

• Chorionic Gonadotropin (therapeutic use)
• Clomiphene (therapeutic use)
• Drug Administration Schedule
• Estrogen Antagonists (administration & dosage)
• Humans
• Male
• Oligospermia (drug therapy)
• Sperm Count (drug effects)